Health Technology Assessment Unit

Publications


Cost Analysis

Weaver C, Clement FM, Campbell N, James MT, Klarenbach S, Hemmelgarn BR, Tonelli M, McBrien KA for the Alberta Kidney Disease Network (AKDN) and the Interdisciplinary Chronic Disease Collaboration (ICDC).  Health care costs attributable to hypertension: a Canadian population-based cohort study.  Hypertension. 2015 Sep;66(3):502-8

Leggett LE, Hauer T, Martin BJ, Manns B, Aggarwal S, Arena R, Austford LD, Meldrum D, Ghali W, Knudtson ML, Norris CM, Stone JA, Clement F. Optimizing Value from Cardiac Rehabilitation: A Cost-Utility Analysis Comparing Age, Sex, and Clinical Subgroups. Mayo Clinical Proceedings. 2015, August; 90(8):1011-20.

Coward S, Heitman S, Clement FM, Hubbard J, Proulx M, Zimmer S, Panaccione R, Seow C, Leung Y, Datta N, Ghosh S, Kaplan G.  Ulcerative Colitis Associated Hospitalization Costs: A Population-Based Study.Canadian Journal of Gastroenterology and Hepatalogy. Can J Gastroenterol Hepatol. 2015 Jun 16. pii: 16814.

Pharmaceuticals

Campbell DJT, Manns BJ, Soril LJJ, Clement F. Comparison of Canadian public medication insurance plans and the impact on out-of-pocket costs. CMAJ Open. 2017 Nov 22;5(4):E808-E813. doi: 10.9778/cmajo.20170065.

Campbell DJ, Soril LJ, Clement F. Impact of Cost-Sharing Mechanisms on Patient-Borne Medication Costs. JAMA Internal Medicine. November 2016;176(11).

Parkinson B, Sermet C, Clement FM, Crausaz S, Godman B, Garner S, Choudhury M, Pearson S, Viney R, Lopert R, Elshaug A.  Disinvestment and Value-Based Purchasing Strategies for Pharmaceuticals: An International Review.  Pharmacoeconomics. 2015 Jun 6. [Epub ahead of print]


Health Technology Reassessment

Soril LJJ, Noseworthy TW, Stelfox HT, Zygun DA, Clement FM. A retrospective observational analysis of red blood cell transfusion practices in stable, non-bleeding adult patients admitted to nine medical-surgical intensive care units. J Intensive Care. 2019 Apr 4;7:19. doi: 10.1186/s40560-019-0375-3. 

Soril LJJ, Noseworthy TW, Stelfox HT, Zygun DA, Clement FM. Facilitators of and barriers to adopting a restrictive red blood cell transfusion practice: a population-based cross-sectional survey. CMAJ Open. 2019 Apr 23;7(2):E252-E257. doi: 10.9778/cmajo.20180209. 

Soril LJJ, Niven DJ, Esmail R, Noseworthy TW, Clement FM. UNTANGLING, UNBUNDLING, AND MOVING FORWARD: FRAMING HEALTH TECHNOLOGY REASSESSMENT IN THE CHANGING CONCEPTUAL LANDSCAPE. Int J Technol Assess Health Care. 2018 Jan;34(2):212-217. doi: 10.1017/S0266462318000120.

Soril LJJ, Seixas BV, Mitton C, Bryan S, Clement FM. Moving low value care lists into action: prioritizing candidate health technologies for reassessment using administrative data. BMC Health Serv Res. 2018 Aug 15;18(1):640. doi: 10.1186/s12913-018-3459-1.

Soril LJJ, Noseworthy TW, Dowsett LE, Memedovich K, Holitzki HM, Lorenzetti DL, Stelfox HT, Zygun DA, Clement FM. Behaviour modification interventions to optimise red blood cell transfusion practices: a systematic review and meta-analysis. BMJ Open. 2018 May 18;8(5):e019912. doi: 10.1136/bmjopen-2017-019912.

Soril LJJ, MacKean G, Noseworthy TW, Leggett LE, Clement F. Achieving Optimal Technology Use: A Proposed Model for Health Technology Reassessment. SAGE Open Medicine. April 2017; 5.

Soril LJ, Clement F, Noseworthy TW. Bioethics, Health Technology Reassessment, and Management. Healthc Manage Forum. Nov 2016; 29(6).

Noseworthy, T.W., Clement, F.M. Health Technology Reassessment: Scope, Methodology and Language. Int J Technol Assess Health Care; 2012; 28(3). Link to PubMed

MacKean, G., Noseworthy, T., Elshaug, A. G., Leggett, L., Littlejohns, P., Berezanski, J., & Clement, F. (2013). Health Technology Reassessment: The Art of the Possible. International journal of technology assessment in health care29(04), 418-423.

Leggett, L.E., MacKean, G., Noseworthy, T.W., Sutherland, L.R., Clement, F.M. 2013, 10:38, Health Technology Reassessment of Non-Drug Technologies: A Survey and Key Informant Interviews. Health Policy.

Leggett, L.E., Noseworthy, T.W., Zarrabi, M., Lorenzetti, D., Sutherland, L.R., Clement, F.M. Health Technology Reassessment of Non-Drug Technologies: Current Practices. Int J Technol Assess Health Care; 2012; 28(3). Link to PubMed


Policy

Hofmeister M, Memedovich A, Brown S, Saini M, Dowsett LE, Lorenzetti D, McCarron T, MacKean G, Clement F. Effectiveness of Neurostimulation Technologies for the Management of Chronic Pain: A Systematic Review. Neuromodulation. 2019. In press

Hofmeister M, Dowsett LE, Lorenzetti DL, Clement F. Ultrasound- versus fluoroscopy-guided injections in the lower back for the management of pain: a systematic review. Eur Radiol. 2019. Epub ahead of print. doi: 10.1007/s00330-019-06065-3

Hofmeister M, Memedovich A, Dowsett LE, et al. Palliative care in the home: a scoping review of study quality, primary outcomes, and thematic component analysis. BMC Palliat Care. 2018;17(1):41. Published 2018 Mar 7. doi:10.1186/s12904-018-0299-z

Spackman E, Haines-Saah R, Danthurebandara VM, Dowsett LE, Noseworthy T, Clement FM. Marijuana Use and Perceptions of Risk and Harm: A Survey among Canadians in 2016. Usage de la marijuana et perceptions des risques et dommages : sondage auprès des Canadiens en 2016. Healthc Policy. 2017;13(1):17–27. doi:10.12927/hcpol.2017.25194

Soril LJJ, Adams T, Phipps-Taylor M, Winblad U, Clement F. Is Canadian Healthcare Affordable? A Comparative Analysis of the Canadian Healthcare System from 2004 to 2014. Healthc Policy. 2017 Aug;13(1):43-58.

Holitzki, H., Dowsett, L.E., Spackmand, E., Noseworthy, T. & Clement, F. Health Effects of Exposure to Second-and Third-Hand Marjiuana Smoke: A Systematic Review. CMAJ Open, 5(4), E814. November 2017.

Dowsett LE, Clement F, Coward S, Lorenzetti D, Noseworthy T, Sevick L, Spackman E. Effectiveness of Surgical Treatment for Tarlov Cysts. Clin Spine Surg. 2017.

Dowsett LE, Coward S, Lorenzetti D, MacKean G, Clement F. Living with Hepatitis C Virus: A Systematic Review and Narrative Synthesis of Qualitative Literature. Canadian Journal of Gastroenterology and Hepatology. April 2017; 2017.

Coward S, Leggett L, Kaplan G, Clement F. Cost-effectiveness of Screening for Hepatitis C Virus: A Systematic Review of Economic Evaluations. BMJ Open. August 2016

Soril L JJ, Leggett LE, Lorenzetti DL, Noseworthy T, Clement FM. Characteristics of Frequent Users of the Emergency Department: A Systematic Review of International Healthcare Systems.  May 2016

Ho C, Cimon K, Weeks L, Mierzwinski-Urban M, Dunfield L, Soril L, Jabr M. Point-of-care Troponin Testing in Patients with Symptoms Suggestive of Acute Coronary Syndrome: A Health Technology Assessment. Canadian Agency for Drugs and Technologies in Health. March 2016.

Leggett LE, Khadaroo RG, Holroyd-Leduc J, Lorenzetti DL, Hanson H, Wagg A, Padwal R, Clement FM.  Measuring resource utilization: A systematic review of validated self-reported questionnaires.  Medicine.  2016 March 2016; 95(10).

Josephson C, Sauro K, Clement FM, Wiebe S, Jette N.  Medical versus invasive therapy in AVM-related epilepsy: systematic review and meta-analysis.  Neurology. 2015 Dec 7.

Stelfox HT, Niven DJ, Clement FM, Bagshaw SM, Cook DJ, McKenzie E, Potestio ML, Doig CJ, O'Neill B, Zygun D; Critical Care Strategic Clinical Network, Alberta Health Services. Stakeholder Engagement to Identify Priorities for Improving the Quality and Value of Critical Care. PLoS One. 2015 Oct 22;10(10)

Leggett LE, Soril JJ, Coward S, Lorenzetti D, MacKean G, Clement FM. Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression in Adult and Youth Populations: A systematic literature review and meta-analysis. Primary care Companion for CNS Disorders. 2015, November.

Thommasen A, Clement FM, Kinniburgh D, Lau, C, Gui M, Viczko J, Guggisberg K, Thomas R, Turiin T, Wesenberg J, Abdullah A, Hnydky W, Naugler C.  Canadian Family Physician Knowledge and Attitudes Toward Laboratory Utilization Management.  Clinical Biochemistry. 2015 Sep 26

Khadaroo R, Padwal R, Wagg A, Clement FM, Warkentin L, Holroyd-Leduc J.  Optimizing senior's surgical care - Elder-Friendly Approaches to the Surgical Environment (EASE) Study: rationale and objectives.  BMC Health Services Research.  2015 Aug 21;15(1):338

Soril LJJ, Leggett, LE, Lorenzetti, DL, Silvius, J, Robertson, D, Mansell, L, Holroyd-Leduc, J, Noseworthy, TW, Clement, FM. Effective Use of the Built Environment to Manage Behavioural and Psychological Symptoms of Dementia: A Systematic Review. PLoS ONE. 2014, Dec: 9(12).

Soril LL, Leggett LE, Lorenzetti DL, Noseworthy TW, Clement FM. Reducing Frequent Visits to the Emergency Department: A Systematic Review of Interventions.  PLoS One. 2015 Apr 13;10(4)

Leggett, LE, Soril LJJ, Lorenzetti DL, Noseworthy T, Steadman R, Tiwana S, Clement F. Radiofrequency Ablation for Chronic Low Back Pain: A Systematic Review of Randomized Controlled Trials. Pain Research and Management. 2014,Oct: 19(5):146-153.

Leggett LE, Lorenzetti D, Noseworthy T, Tiwana S, MacKean G, Clement FM.  Experiences and Attitudes towards Risk of Recurrence Testing in Women with Breast Cancer: A Systematic Review. Breast Cancer Res Treat. 2014 Apr;144(3):457-65.

Leggett LE, Soril JJ, Lorenzetti DL, Noseworthy T, Steadman R, Tiwana S, Clement F. Radiofrequency Ablation for Chronic Low Back Pain: A Systematic Review of Randomized Controlled Trials. Pain Research and Management 2014, IN PRESS.

Steadman, R., Myers, R.P., Leggett, L.E., Lorenzetti, D., Noseworthy, T.W., Rose, S., Sutherland, L.R., Clement, F.M. 2013, 27:(3), A Health Technology Assessment of Transient Elastography in Adult Liver Disease. The Canadian Journal of Gastroenterology.

Leggett, L. E., Lorenzetti, D. L., Noseworthy, T., Tiwana, S., MacKean, G., & Clement, F. (2014). Experiences and attitudes toward risk of recurrence testing in women with breast cancer: a systematic review. Breast cancer research and treatment144(3), 457-465.

Cepoiu-Martin M, Faris P, Lorenzetti D, Prefontaine E, Noseworthy T, Sutherland L. Artificial Cervical Disc Arthroplasty: A Systematic Review. Spine 2011; 36:E1623-E1633.

Cepoiu-Martin M, Rose S, Lorenzetti D, Youseffi M, Noseworthy T, Sutherland L. (In press). A meta-analysis and meta-regression analysis of recent data on INR management using portable prothrombin systems. Clinical Applied Thrombosis and Haemostasis.

Cepoiu-Martin M, Rose S, Lorenzetti D, Youseffi M, Noseworthy T, Sutherland L. (In press). A meta-analysis and meta-regression analysis of recent data on INR management using portable prothrombin systems. Clinical Applied Thrombosis and Haemostasis.

Cepoiu-Martin M, Faris P, Lorenzetti D, Prefontaine E, Noseworthy T, Sutherland L. Artificial Cervical Disc Arthroplasty: A Systematic Review. Spine 2011; 36:E1623-E1633.